Macrophagesarecellsdifferentiatedfromcirculatingbonemarrow-derivedmonocytes.ThemainfunctionofmacrophagesistoremovecellulardebrisanddestroyinvADIngpathogens.HumanHepaticMacrophages(HHMa),whicharealsoknownasKupffercells,residewithinthelumenofliversinusoids.HHMaprotecttheliverbyrespondingtopathogensandmetastaticcells,whiletoleratingharmlessselfandforeignantigens,whichenterviabloodflowthroughtheportalveinandhepaticartery[1].Recentstudieshaveshownthathepaticmacrophagesplayanimportantroleinfibrosis,liverinflammation,fattyliverdisease,andlivertransplantation[2-4].HHMaareanexcellentmodelforstudyingmacrophagefunctionsundernormalphysiologicalandpathologicalconditions.

HHMafromSciencellResearchLaboratoriesareisolatedfromhumanliver.HHMaarecryopreservedafterpurificationanddeliveredfrozen.Eachvialcontains>1x10^6cellsin1mlvolume.HHMaarecharacterizedbyimmunofluorescencewithantibodytoF4/80.HHMaarenegativeforHIV-1,HBV,HCV,mycoplasma,bacteria,yeastandfungi.HHMaareguaranteedtofurthercultureintheconditionsprovidedbyScienCellResearchLaboratories;however,HHMaarenotrecommendedforexpandingorlong-termculturessincethecellsdonotproliferateinregularculture. 

RecommendedMedium
ItisrecommendedtouseMacrophageMedium(MaM,Cat.#1921)forculturingHHMainvitro

Specifications:

美国Sciencell 研究实验室（ScienCell）是一家生物技术公司，其宗旨是研究和细胞和细胞发育相关的实验和治疗的产品。该ScienCell技术提供了高质量的正常人体和动物的各种细胞，细胞培养基和试剂，中补充，细胞源性核糖核酸，基因和蛋白质的研究团体。在ScienCell科学家还在研究和开发细胞治疗策略，将大大改善通过实现细胞的能力，打击贩运退行性疾病的生活质量。我们的总部设在加利福尼亚州圣迭戈，并于1999年设立。