Macrophagesarecellsdifferentiatedfromcirculatingbonemarrow-derivedmonocytes.TheirmainfunctionistoremovecellulardebrisandinvADIngpathogens.Hepaticmacrophages,whicharealsoknownasKupffercells,residewithinthelumenofliversinusoids.Hepaticmacrophagesprotecttheliverbyrespondingtopathogensandmetastaticcells,whilsttoleratingharmlessselfandforeignantigens,whichenterviabloodflowthroughportalveinandhepaticartery[1].Recentstudieshaveshownthathepaticmacrophagesplayanimportantroleinfibrosis,liverinflammation,alcoholicliverdisease,fattyliverdisease,livertransplantationandmore[2-5].Macrophagesisolatedfromfreshratlivertissueserveasanexcellentmodelforstudyingtheirfunctionsundernormalphysiologicalandpathologicalconditions.
RHMafromScienCellResearchLaboratoriesareisolatedfrompostnatalday2CD®IGSratliver.RHMaarecryopreservedafterpurificationanddeliveredfrozen.Eachvialcontains>1x10^6cellsin1mlvolume.RHMaarecharacterizedbyimmunofluorescencewithantibodytoF4/80.RHMaarenegativeformycoplasma,bacteria,yeast,andfungi.RHMaisguaranteedtofurthercultureintheconditionprovidedbySciencellResearchLaboratories;however,RHMaarenotrecommendedforexpandingorlong-termculturessincethecellsdonotproliferateinregularculture.
RecommendedMedium
ItisrecommendedtouseMacrophageMedium(MaM,Cat.#1921)forculturingRHMainvitro.
CatalogNo. | R5340 |
CountryofManufacture | UnitedStates |
ProductCode | RHMa |
Size/Quantity | 1x10^6cells/vial |
ProductUse | RHMaareforresearchuseonly.Theyarenotapprovedforhumanoranimaluse,orforapplicationininvitrodiagnosticprocedures. |
Storage | Transfercellsdirectlyandimmediatelyfromdryicetoliquidnitrogenuponreceivingandkeepthecellsinliquidnitrogenuntilcellcultureisneededforexperiments. |
ShippingInfo | Dryice. |
References | [1].WynnTAandBarronL.(2010).SeminLiverDis.30:245-57.[2].LiaskouE,WilsonDVandOoYH.(2012).MediatorsInflamm.2012:949157.[3].AjakaiyeM,JacobA,WuR,ZhouM,etal.(2011).BiochemBiophysResCommun.409:406-411.[4].BieghsV,VerheyenF,vanGorpPJ,HendrikxT,etal.(2012)PLoSOne.7:e34378.[5].TianY,JochumW,GeorgievP,MoritzW,etal.(2006).ProcNatlAcadSciUSA.103:4598-4603.[6].SekiE,DeMinicisS,InokuchiS,TauraK,etal.(2009).Hepatology.50:185-197.[7].GordonSandTaylorP.(2005).NatureReviewsImmunology.5:953-964. |
美国Sciencell 研究实验室(ScienCell)是一家生物技术公司,其宗旨是研究和细胞和细胞发育相关的实验和治疗的产品。该ScienCell技术提供了高质量的正常人体和动物的各种细胞,细胞培养基和试剂,中补充,细胞源性核糖核酸,基因和蛋白质的研究团体。在ScienCell科学家还在研究和开发细胞治疗策略,将大大改善通过实现细胞的能力,打击贩运退行性疾病的生活质量。我们的总部设在加利福尼亚州圣迭戈,并于1999年设立。