Thisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
GM-CSFwasinitiallycharacterizedasafactorthatcansupporttheinvitrocolonyformationofgranulocyte-macrophageProgenitors.Itisalsoagrowthfactorforerythroid,megakaryocyte,andeosinophilprogenitors.GM-CSFisproducedbyTcells,Bcells,macrophages,mastcells,endothelialcells,fibroblasts,andADIpocytesinresponsetocytokineorinflammatorystimuli.Onmaturehematopoieticcells,GM-CSFactsasaprosurvivalfactorandactivateseffectorfunctionsofgranulocytes,monocytes/macrophages,andeosinophils.ItpromotesaTh1biasedimmuneresponse,angiogenesis,allergicinflammation,andthedevelopmentofautoimmunity.The22kDaglycosylatedGM-CSF,similartoIL-3andIL-5,isacytokinewithacoreoffourαundled?-helices.MaturemouseGM-CSFshares49%-54%aminoacidsequenceidentitywithcanine,feline,human,andporcineGM-CSFand69%withratGM-CSF.TheactivityofGM-CSFisspeciesspecificbetweenhumanandmouse.MouseGM-CSFisonlyweaklyactiveonratcells,althoughratGM-CSFisfullyactiveonmousecells.

Specifications:

CatalogNo.	122-03
CountryofManufacture	UnitedStates
ProductCode	rmGM-CSF
Size/Quantity	5μg
ProductUse	Thisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
Storage	Storeat-20°Cafterreceiving.UponReconstitution,storeat2-8°Cforuptooneweek.FormaximalstABIlity,aliquotandstoreat-20°C.Avoidrepeatedfreeze/thawcycles.
ShippingInfo	Dryice
Synonyms	CSF-2,MGI-1GM,GM-CSF,Pluripoietin-alpha,Molgramostin,Sargramostim
AASequence	MAPTRSPITVTRPWKHVEAIKEALNLLDDMPVTLNEEVEVVSNEFSFKKLTCVQTRLKIFEQGLRGNFTKLKGALNMTASYYQTYCPPTPETDCETQVTTYADFIDSLKTFLTDIPFECKKPVQK
Source	Escherichiacoli
MolecularWeight	Approximately14.2kDaglobularproteinconsistingof124aminoacidsresidues.
Purity	>95%bySDS-PAGEandHPLCanalyses.
BIOLOGicalActivity	Fullybiologicallyactive.TheED50is?0.2ng/ml,correspondingtoaspecificactivityof?5x10^6units/mg,asdeterminedbymurineFDC-P1cellproliferation.
PhysicalAppearance	Whitelyophilizedpowder.
Formulation	Lyophilizedfroma0.2μmfilteredsolutioninPBS,pH7.4.
Endotoxin
Reconstitution	Reconstituteinsteriledistilledwatercontaining0.1%BSAtoaconcentrationof0.1-1.0mg/mL.

美国Sciencell 研究实验室（ScienCell）是一家生物技术公司，其宗旨是研究和细胞和细胞发育相关的实验和治疗的产品。该ScienCell技术提供了高质量的正常人体和动物的各种细胞，细胞培养基和试剂，中补充，细胞源性核糖核酸，基因和蛋白质的研究团体。在ScienCell科学家还在研究和开发细胞治疗策略，将大大改善通过实现细胞的能力，打击贩运退行性疾病的生活质量。我们的总部设在加利福尼亚州圣迭戈，并于1999年设立。